[尾形 健明]
[産学官民連携のための研究者総覧へ]
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◎山形大学／工学部／物質化学工学科／環境エネルギー化学講座
尾形 健明（OGATA Tateaki）
1948年生 ／教授 【磁気共鳴化学，生体計測化学，無機化学】
○研究テーマ： (1)動植物内フリーラジカルのin vivo計測用電子スピン共鳴（ESR）法の開発を行い，生体内におけるフリーラジカルの検出とCT画像計測から反応機構および生体機能解明を試みる。 (2)抗酸化剤によるスーパーオキシド，ヒドロキシルラジカル，一重項酸素などの活性酸素の消去活性機能を評価するためのESRスピントラップ法を開発し，種々の食材の抗酸化機能を評価する。 (3)炭素材料などの素材の機能評価のため，内在性フリーラジカルをプローブとするESR法により，フリーラジカル挙動を解析する。 （4)フィールドワーク対応のポータブルESR装置の開発を行い，環境中のフリーラジカル挙動を解析する。
○主な授業科目： 無機化学Ⅱ，生物無機化学（工学部），生物無機化学特論，磁気共鳴計測特論（理工学研究科）
○学会・社会活動等： 日本化学会，日本分析化学会，日本農芸化学会，環境科学会，日本フリーラジカル学会，電子スピンサイエンス学会
うこぎ食品研究会
研究業績
○ESR spatiotemporal measurement by using the rapid field scan L-band ESR-CT system for determination of rate constants of nitroxide radical reduction, （共著）,Anal. Sci., 13（2）, 269-272 （1997)(1997)
○In vivo ESR analysis of nitroxide radicals injected into a rat by a flexible surface-coil-type resonator as as endoscope- or a stethoscope-like device（共著）,MAGMA, 5, 99-104 (1997)(1997)
○Temporal brain imaging by a rapid scan ESR-CT system in rats receiving intraperitoneal injection of a methyl ester nitroxide radical（共著）,Magn. Reson. Imag., 15（9）, 1079-1084 （1997）(1997)
○Surface-coil-type resonators for in vivo temporal ESR measurements in different organs of nitroxide-treated rats（共著）,Appl. Magn. Reson., 18, 575-582 (2000)(2000)
○Determination of superoxide scavenging activity of a sample containing xanthine oxidase inhibitor by ESR spin trapping（共著）,Anal. Sci., 16, 1029-1032 (2000)(2000)
○In vivo ESR study on hepatic reduction of a nitroxide radical after administration of glucose in rats（共著）,Life, 51, 45-48 (2001)(2001)
○Syntheses of Water-solble Endoperoxides as a Singlet Oxygen Source（共著）,ITE Letters, 2, 98-101 (2001)(2001)
○Automatic Coupling Crontrol of a Loop-Gap Resonator by a Variable Capacitor Attached Coupling Coil for EPR Measurements ant 650 MHz（共著）,J. Magn. Reson., 149, 29-35 (2001)(2001)
○Superoxide scavenging activity of sixty Chinese medicines determined by ESR spin-trapping method using electrogenerated superoxide（共著）,Yakugaku Zasshi, 121, 265-270 (2001)(2001)
○ESR Imaging on a Solid-tumor-bearing Mouse Using Spin-labeled Dextran（共著）,Biosci. Biotechnol. Biochem., 65, 787-794 (2001)(2001)
○Determination of Absolute Concentration of Nitoxide Radical by Radio-Frequecy EPR Imaging（共著）,Appl. Magn. Reson., 20, 257-263 (2001) (2001)
○ZnO Marker for a Radio Frequency ESR Spectrometer（共著）,Chem. Lett., 2001, 928-929(2001)
○Influence of lens effect in a sample with large dielectric constant in a loop-gap resonator on EPR signal intensity at 700 MHz（共著）,Appl. Magn. Reson., 21, 97-103 (2001)(2001)
○ESR-CT measurement on mice using long-life radicals（共著）,Anal. Sci., 17 Supplement, i1423-i1425 (2001)(2002)
○Quantitative Measurement of Nitroxyl Radical in a Rat Head and a Mouse by Using an In Vivo ESR Imaging system（共著）,Anal. Sci., 17 Supplement, i1433-i1435 (2001)(2002)
○Reversible potentials of reduction and oxidation processes on the novel spin probe TAM in an aqueous solution（共著）,ITE Lett., 3, 351-352 (2002)(2002)
○Preparation of SnO2 thin films by the oxidative-soak-coating method（共著）,J. Mater. Sci. Lett., 21, 1241-1243 (2002)(2002)
○Local pharmacokinetic analysis of a stable spin probe in mice by in vivo L-band ESR with surface-coil-type resonators（共著）,Free Radical Research, 36 (10), 1115-1125 (2002)(2002)
○Nondestructive Real-Time Monitoring of the Redox Status in a Potted Plant by Using a Surface-Coil-Type ESR Resonator（共著）,Chem. Lett., 2001, 1122-1123(2002)
○Development of resonator for an ESR/NMR hybirid imaging system（共著）,Jpn. J. Med. Phys., 23(4), 75-81 (2003).(2003)
○Open-type EPR spectrometer to measure electron spins of a sample located outside a resonator（共著）,Appl. Magn. Reson., 25, 55-63(2003)
○Direct observation of the redox states of frozen cherry buds by a unique in vivo ESR（共著）,Biochem. Biophys. Res. Comm., 310, 72-77(2003)
○Evaluation of the hepatic reduction of a nitroxide radical in rats receiving ascorbic acid, glutathione or ascorbic acid oxidase by in vivo electron spin resonance study（共著）,J. Gastroenterology and Hepatology, 19, 99-105(2004)
○Nondestructive monitoring of the nitroxyl radical reduction in Masu Salmon (Oncorhynchus masou) egg using in vivo ESR technique（共著）,ITE Lett., 5(1), 53-55 (2004)(2004)
○Effects of transition metal ions on the oxidation of a redox-probing agent (HTIO) in aqueous solutions（共著）,ITE Lett., 5(3), 276-278 (2004)(2004)
○A drastic redox response in plants by environmental stress observed through a novel spin probe（共著）,ITE Letters, 5(5), 492-495 (2004)(2004)
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